Published Studies by MeVac

1. Phenotypic detection of carbapenemase and AmpC-β-lactamase production among extended spectrum β-Lactamase (ESBL)-producing Escherichia coli and Klebsiella spp. isolated from clinical specimens. Antibiotics 2023;13:31.Garba Z, Kaboré B, Bonkoungou IJO, Natama MH, Rouamba T, Haukka K, Kirveskari JP, Tinto H, Sangaré L, Barro N, Kantele A.
2. Mucosal-Associated Invariant T Cells are not susceptible in vitro to SARS-CoV-2 infection but accumulate into the lungs of COVID-19 patients. Virus Res 2024;341:199315.Huang X, Kantonen J, Nowlan K, Nguyen NA, Jokiranta ST, Kuivanen S, Heikkilä N, Mahzabin S, Kantele A, Vapalahti O, Myllykangas L, Heinonen S, Mäyränpää MI, Strandin T, Kekäläinen E.
3. Long COVID-associated symptoms prevalent in both SARS-CoV-2 positive and negative individuals: A prospective follow-up study. New Microbes New Infect 2023;56:101209.Kantele A, Paajanen J, Pietilä JP, Vapalahti O, Pakkanen SH, Lääveri T.
4. International travel increases risk of urinary tract infection caused by extended-spectrum beta-lactamase-producing Enterobacterales-three-arm case-control study. J Travel Med 2024;31:taad155. Patjas A, Martelius A, Ollgren J, Kantele A.
5. High-volume evacuation mitigates viral aerosol spread in dental procedures. Sci Rep.2023 Nov 3;13(1):18984. doi: 10.1038/s41598-023-46430-3. PMID: 37923796; PMCID:PMC10624893. Malmgren R, Välimaa H, Oksanen L, Sanmark E, Nikuri P, Heikkilä P, Hakala J, Ahola A, Yli-Urpo S, Palomäki V, Asmi E, Sofieva S, Rostedt A, Laitinen S, Romantschuk M, Sironen T, Atanasova N, Paju S, Lahdentausta-Suomalainen L.
6. Treatment of Dientamoeba fragilis: A retrospective Finnish analysis of faecal clearance and clinical cure comparing four antiprotozoal drugs. New Microbes New Infect 2023;54:101179. Pietilä JP, Häkkinen TA, Pakarinen L, Ollgren J, Kantele A. 
7. Image-based and machine learning-guided multiplexed serology test for SARS-CoV-2. Cell Rep Methods 2023;3:100565. Pietiäinen V, Polso M, Migh E, Guckelsberger C, Harmati M, Diosdi A, Turunen L, Hassinen A, Potdar S, Koponen A, Sebestyen EG, Kovacs F, Kriston A, Hollandi R, Burian K, Terhes G, Visnyovszki A, Fodor E, Lacza Z, Kantele A, Kolehmainen P, Kakkola L, Strandin T, Levanov L, Kallioniemi O, Kemeny L, Julkunen I, Vapalahti O, Buzas K, Paavolainen L, Horvath P, Hepojoki J. 
8. Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater. Arch Virol 2023;168:228. Kolsi A, Haukka K, Dougnon V, Agbankpè AJ, Fabiyi K, Virta M, Skurnik M, Kantele A, Kiljunen S. 
9. Coadministered pneumococcal conjugate vaccine decreases immune response to hepatitis A vaccine: a randomized controlled trial. Clin Microbiol Infect 2023;S1198–743X(23)00387–7. Riekkinen M, Pakkanen SH, Hutse V, Roukaerts I, Ollgren J, Käyhty H, Herzog C, Rombo L, Kantele A. 
10. Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults: symptomatic COVID-19 only contracted by those without recent infection. Epidemiol Infect 2023;151:e113. Riekkinen M, Kajova M, Eriksson M, Luukkainen A, Holmberg V, Aro T, Pakkanen SH, Miettinen S, Montonen R, Smura T, Lääveri T, Kantele A. 
11. The highly diverse plasmid population found in Escherichia coli colonising travellers to Laos and its role in antimicrobial resistance gene carriage. Microbial Genomics 2023;9:mgen001000. Snaith AE, Dunn SJ, Moran RA, Newton PN, Dance DAB, Davong V, Kuenzli E, Kantele A, Corander J, McNally A. 
12. Streptococcus anginosus: a stealthy villain in deep odontogenic abscesses. Odontology. 2023 Apr;111(2):522-530. doi: 10.1007/s10266-022-00763-z. Epub 2022 Nov 8. PMID:36346473; PMCID: PMC10020309. Furuholm J, Uittamo J, Rautaporras N, Välimaa H, Snäll J.
13. Safety and immunogenicity of ETVAX®, an oral inactivated vaccine against enterotoxigenic Escherichia coli diarrhoea: a double-blinded, randomised, placebo-controlled trial among Finnish travellers to Benin, West-Africa. Journal of Travel Medicine 2023;30:taad045. Kantele A, Riekkinen M, Jokiranta TS, Pakkanen SH, Pietilä J-P, Patjas A, Eriksson M, Khawaja T, Klemets P, Marttinen K, Siikamäki H, Lundgren A, Holmgren J, Lissmats A, Carlin N, Svennerholm AM.
14. Bivalent prefusion F vaccine in pregnancy to prevent RSV illness in infants. N Engl J Med. 2023;388:1451–64. Kampmann B, Madhi SA, Munjal I, Simões EAF, Pahud BA, Llapur C, Baker J, Pérez Marc G, Radley D, Shittu E, Glanternik J, Snaggs H, Baber J, Zachariah P, Barnabas SL, Fausett M, Adam T, Perreras N, Van Houten MA, Kantele A, Huang LM, Bont LJ, Otsuki T, Vargas SL, Gullam J, Tapiero B, Stein RT, Polack FP, Zar HJ, Staerke NB, Duron Padilla M, Richmond PC, Koury K, Schneider K, Kalinina EV, Cooper D, Jansen KU, Anderson AS, Swanson KA, Gruber WC, Gurtman A; MATISSE Study Group.
15. Seasonal variation of diarrhoeal pathogens among Guinea-Bissauan children under five years of age. Plos Negl Trop Dis 2023;17:e10011179. Mero S, Lääveri T, Ursing J, Rombo L, Kofoed PE, Kantele A. 
16. Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age. N Engl Med 2023;388:621–34. Muñoz FM, Sher LD, Sabharwal C, Gurtman A, Xu X, Kitchin N, Lockhart S, Riesenberg R, Sexter JM, Czajka H, Paulsen GC, Maldonado Y, Walter EB, Talaat KR, Englund JA, Sarwar UN, Hansen C, Iwamoto M, Webber C, Cunliffe L, Ukkonen B, Martínez SN, Pahud BA, Munjal I, Domachowske JB, Swanson KA, Ma H, Koury K, Mather S, Lu C, Zou J, Xie X, Shi PY, Cooper D, Türeci Ö, Şahin U, Jansen KU, Gruber WC; C4591007 Clinical Trial Group.
17. Metagenomic analysis of the abundance and composition of antibiotic resistance genes in hospital wastewater in Benin, Burkina Faso, and Finland. mSphere 2023;8:e0053822. Markkanen MA, Haukka K, Pärnänen KMM, Dougnon VT, Bonkoungou IJO, Garba Z, Tinto H, Sarekoski A, Karkman A, Kantele A, Virta MPJ.
18. Safety and immunogenicity of an investigational respiratory syncytial virus vaccine (RSVPreF3) in mothers and their infants: a phase 2 randomized trial. J Infect Dis 2023;jiad024. Bebia Z, Reyes O, Jeanfreau R, Kantele A, De Leon RG, García Sánchez M, Banooni P, Gardener GJ, Bartha Rasero JL, Encinas Pardilla MB, Langley JM, Di Leo CM, Botelho-Nevers E, Buttery J, Laurichesse H, Madhi SA, García AM, Stanley T, Barjat T, Griffith R, Castrejón-Alba MM, de Heusch M, Dieussaert I, Hercor M, Lese P, Qian H, Tullio AN, Henry O. 
19. A comprehensive assessment of four whole blood stabilisers for flow-cytometric analysis of leukocyte populations. Cytometry A 2022;103:313-4. Nguyen NA, Huang X, Cabrera LE, Pekkarinen PT, Nowlan K, Strandin T, Kantele A, Vapalahti O, Heinonen S, Kekäläinen E. 
20. A Two-week vacation in the tropics and psychological well-being – an observational follow-up study. Int J Environ Res Public health 2022;19:10381. Laukkala T, Rosenström T, Kantele A.
21. Doxycycline as an antimalarial: impact on travellers’ diarrhoea and doxycycline resistance among various stool bacteria – prospective study and literature review.Travel Medicine and Infectious Diseases 2022;49:102403. Kantele A, Mero S, Lääveri T. 
22. Scent dogs in the detection of COVID-19 − a triple-blinded randomised trial at the airport and a deployment in a real-life setting. BMJ Global Health 2022;7:e008024. Kantele A, Paajanen J, Turunen S, Pakkanen SH, Patjas A, Itkonen L, Heiskanen E, Desquilbet L, Vapalahti O, Hielm-Björkman A. 
23. Long-lasting T cell responses in BNT162b2 COVID-19 mRNA vaccinees and COVID-19 convalescent patients. Frontiers Immunol 2022;13:869990. Hurme A, Jalkanen P, Heroum J, Liedes O, Vara S, Melin M, Teräsjärvi J, He Q, Pöysti S, Hänninen A, Oksi J, Vuorinen T, Kantele A, Tähtinen PA, Ivaska L, Kakkola L, Lempainen J, Julkunen I. 
24. Comparative analysis of BNT162b2, mRNA-1273 and ChAdOx1 COVID-19 vaccine induced antibody responses and the 3rd BNT162b2 vaccine induced neutralizing antibodies against Delta and Omicron variants. Nature Communications 2022;13:2476. Belik M, Jalkanen P, Lundberg R, Reinholm A, Laine L, Väisänen E, Skön M, Tähtinen P, Ivaska L, Pakkanen SH, Häkkinen HK, Ortamo E, Pasternack A, Ritvos MA, Naves RA, Miettinen S, Sironen T, Vapalahti O, Ritvos O, Österlund P, Kantele A, Lempainen J, Kakkola L, Kolehmainen P, Julkunen I.
25. International travel and travelers’ diarrhea – increased risk of urinary tract infection. Travel Medicine and Infectious Diseases 2022;48:102331. Patjas A, Kantele A. 
26. Vaccine-Induced Antibody Responses against SARS-CoV-2 variants-of-concern six months after the BNT162b2 COVID-19 mRNA vaccination. Microbiol Spectr 2022;10:e0225221. Jalkanen P, Kolehmainen P, Haveri A, Huttunen M, Laine L, Österlund P, Tähtinen PA, Ivaska L, Maljanen S, Reinholm A, Belik M, Smura T, Häkkinen HK, Ortamo E, Kantele A, Julkunen I, Lempainen J, Kakkola L. 
27. European hospitals as source of multidrug-resistant bacteria: Analysis of travellers screened in Finland after hospitalization abroad. J Travel Med 2022;20:taac022. Kajova M, Khawaja T, Kantele A. 
28. Three-dose versus four-dose primary schedules for tick-borne encephalitis (TBE) vaccine FSME-immun for those aged 50 years or older: A single-centre, open-label, randomized controlled trial. Vaccine 2022;40:1299–305. Kantele A, Rombo L, Vene S, Kundi M, Lindquist L, Erra EO. 
29. Synergistic interferon-alpha-based combinations for treatment of SARS-CoV-2 and other viral infections. Viruses 2021;13:2489. Ianevski A, Yao R, Zusinaite E, Lello LS, Wang S, Jo E, Yang J, Ravlo E, Wang W, Lysvand H, Løseth K, Oksenych V, Tenson T, Windisch MP, Poranen MM, Nieminen AI, Nordbø SA, Fenstad MH, Grødeland G, Aukrust P, Trøseid M, Kantele A, Lastauskienė E, Vitkauskienė A, Legrand N, Merits A, Bjørås M, Kainov DE. 
30. Association between first language and SARS-CoV-2 infection rates, hospitalization, intensive care admissions and death in Finland: a population-based observational cohort study. Clinical Microbiology and Infection 2022;28:107–13. Holmberg V, Salmi H, Kattainen S, Ollgren J, Kantele A, Pynnönen J, Järvinen A, Forsblom E, Silén S, Kivivuori S-M, Meretoja A, Hästbacka. J. 
31. APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study. Acta Neuropthol Commun 2021;9:199. Kurki SN, Kantonen J, Kaivola K, Hokkanen L, Mäyränpää MI, Puttonen H; FinnGen, Martola J, Pöyhönen M, Kero M, Tuimala J, Carpén O, Kantele A, Vapalahti O, Tiainen M, Tienari PJ, Kaila K, Hästbacka J, Myllykangas L. 
32. A fluorescent microsphere immunoassay (FMIA) measuring IgG, IgA and IgM antibodies against SARS-CoV-2 spike and nucleoprotein antigens. Microbiology Spectrum 2021;9:e0113121. Solastie A, Virta C, Haveri A, Ekström N, Kantele A, Miettinen S, Lempainen J, Jalkanen P, Kakkola L, Dub T, Julkunen I, Melin M.
33. COVID-19 adenovirus vaccine triggers antibodies against PF4 complexes to activate complement and platelets. Thromb Res 2021;208:129–37. Pitkänen HH, Jouppila A, Helin T, Dulipati V, Kotimaa J, Meri S, Kantele A, Jalkanen P, Julkunen I, Lassila R. 
34. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. N Engl J Med 2022;386:35–46. Walter EB, Talaat KR, Sabharwal C, Gurtman A, Lockhart S, Paulsen GC, Barnett ED, Muñoz FM, Maldonado Y, Pahud BA, Domachowske JB, Simões EAF, Sarwar UN, Kitchin N, Cunliffe L, Rojo P, Kuchar E, Rämet M, Munjal I, Perez JL, Frenck RW Jr, Lagkadinou E, Swanson KA, Ma H, Xu X, Koury K, Mather S, Belanger TJ, Cooper D, Türeci Ö, Dormitzer PR, Şahin U, Jansen KU, Gruber WC; C4591007 Clinical Trial Group.
35. Hospital admissions of refugees, asylum seekers and undocumented migrants: Ten-year retrospective study. Travel Med Infect Dis. 2021;44:102186. Aro T, Kantele A.
36. Direct patient transfers from abroad to Finland in 2010-19: high rates of imported multidrug-resistant bacteria. Eurosurveillance 2021;26:2001360. Kajova M, Khawaja T, Kangas J, Mäkinen H, Kantele A. 
37. Prevalence of diarrhoeal pathogens among children under five years of age with and without diarrhoea in Guinea-Bissau. PLoS Negl Trop Dis. 2021:15:e0009709. Mero S, Timonen S, Lääveri T, Løfberg S, Kirveskari J, Ursing J, Rombo L, Kofoed PE, Kantele A.
38. Characterization of low-density granulocytes in COVID-19. PLoS Pathog. 2021;17:e1009721. Cabrera LE, Pekkarinen PT, Alander M, Nowlan KHA, Nguyen NA, Jokiranta S, Kuivanen S, Patjas A, Mero S, Pakkanen SH, Heinonen S, Kantele A, Vapalahti O, Kekäläinen E, Strandin T. 
39. COVID-19 mRNA vaccine induced antibody responses and 2 neutralizing antibodies against three SARS-CoV-2 variants. Nat Commun. 2021;12:3991. Jalkanen P, Kolehmainen P, Häkkinen HK, Huttunen M, Tähtinen PA, Lundberg R, Maljanen S, Reinholm A, Tauriainen S, Pakkanen SH, Levonen I, Nousiainen A, Miller T, Välimaa H, Ivaska L, Pasternack A, Naves R, Ritvos O, Österlund P, Kuivanen S, Smura T, Hepojoki J, Vapalahti O, Lempainen J, Kakkola L, Kantele A, Julkunen I.
40. Kinetics of neutralizing antibodies of COVID-19 patients tested using clinical D614G, B.1.1.7 and B 1.351 isolates in microneutralization assay. Viruses 2021;13:996. Virtanen J, Uusitalo R, Korhonen EM, Aaltonen K, Smura T, Kuivanen S, Pakkanen SH, Mero S, Patjas A, Riekkinen M, Kantele A, Nurmi V, Hedman K, Hepojoki J, Sironen T, Huhtamo E, Vapalahti O. 
41. Extended-spectrum beta-lactamase-producing strains among diarrheagenic Escherichia coli-prospective traveler study with literature review. J Travel Med J Travel Med. 2021:taab042. Kantele A, Lääveri T.
42. Real-time sampling of travelers shows intestinal colonization by multidrug-resistant bacteria to be a dynamic process with multiple transient acquisitions. Lancet Microbe 2021;2:e151––8.Kantele A, Kuenzli E, Dunn SJ, Dance DAB, Newton PN, Davong V, Mero S, Pakkanen SH, Neumayr A, Hatz C, Snaith A, Kallonen T, Corander J , McNally A.
43. Effects of environmental factors on severity and mortality of COVID-19. Frontiers in Medicine 2021;7:607786. Kifer D, Villar J, Bugada D, Villar-Garcia J, Gudelj I, Menni C, Sudre C, Vučković F, Ugrina I, Lorini LF, Posso M, Bettinelli S, Ughi N, Maloberti A, Epis O, Giannattasio C, Rossetti C, Kalogjera L, Peršec J, OllivereL, Ollivere BJ, Yan H, Cai T, Aithal GP, Sudre C, Steves CJ, Kantele A, Kajova M, Vapalahti O, Sajantila A, Wojtowicz R, Wierzba W, Krol Z, Zaczynski A, Zycinska K, Postula M, Lukšić I, Čivljak R, Markotić A, Brachmann J, Markl A, Mahnkopf C, Murray B, Ourselin S, Valdes AM, Horcajada JP, Castells X, Pascual J, Allegri M, PrimoracD, Spector TD, Barrios C, Lauc G.
44. A 10-Minute "Mix and Read" antibody assay for SARS-CoV-2. Viruses. 2021;13:E143. Rusanen J, Kareinen L, Levanov L, Mero S, Pakkanen SH, Kantele A, Amanat F, Krammer F, Hedman K, Vapalahti O, Hepojoki J.
45. Revisiting travellers’ diarrhoea justifying antibiotic treatment: prospective study. Turunen K, Kantele A. J Trav Med 2020; 28:taaa237. 
46. Bacterial, viral and parasitic pathogens analysed by qPCR: findings from a prospective study of travellers’ diarrhoea. Trav Med Infect Dis 2021;40:101957. Lääveri T, Antikainen J, Mero S, Pakkanen SH, Kirveskari J, Roivainen M, Kantele A. 
47. SARS-CoV-2 infections among healthcare workers at Helsinki University Hospital, Finland, spring 2020: serosurvey, symptoms and risk factors. Travel Med Infect Dis 2021;39:101949. Kantele A, Lääveri T, Kareinen L, Pakkanen SH, Blomgren K, Mero S, Patjas A, Virtanen J, Uusitalo R, Lappalainen M, Järvinen A, Kurkela S, Jääskeläinen AJ, Vapalahti O, Sironen T. 

Meilahti Vaccine Research Center (MeVac) 
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